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Short-bowel rats habitually presented with liver lesions (Figs 4and 10) as well as increased serum values of ALT, AST, and particularly bilirubin (Fig 5), which were all markedly exacer- bated in rats administered diclofenac, and even more so in rats coadministered diclofenac and L-NAME (Figs 5and 9)

The structural healing follows the same inflammatory, proliferative, and remodeling arc as any connective-tissue injury, the same arc that governs a skier rebuilding an ACL graft, and the proposed peptide mechanisms line up most closely with the proliferative and remodeling phases, when new tissue is being built and organized

doi: 10.1039/d1fo02021h 85 TangW